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kusu新蟲 (初入文壇)
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香港大學(xué)李嘉誠醫(yī)學(xué)院招全職博后-生物醫(yī)學(xué)/干細胞/機械傳感/再生醫(yī)學(xué)/單細胞
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香港大學(xué)李嘉誠醫(yī)學(xué)院 生物醫(yī)學(xué)學(xué)院 謝賞恩教授 招聘1-2名全職博后 Kathryn Cheah教授為香港科學(xué)院成員、世界科學(xué)院院士，是一位發(fā)育遺傳學(xué)家。于英國劍橋大學(xué)獲得分子生物學(xué)博士學(xué)位，曾在英國曼徹斯特大學(xué)和帝國癌癥研究基金會從事博士后研究。 在香港大學(xué)，她曾擔(dān)任生物化學(xué)系主任和生殖、發(fā)育與生長中心主任。 由于對基質(zhì)生物學(xué)的貢獻，她被授予英國基質(zhì)生物學(xué)學(xué)會獎?wù)轮v座 2022。 隨著全球人口老齡化，基因組和再生醫(yī)學(xué)將在幫助保持健康成長和生活質(zhì)量方面發(fā)揮關(guān)鍵作用。她使用人類和小鼠胚胎干細胞和轉(zhuǎn)基因小鼠作為模型來研究發(fā)育和疾病，并開發(fā)治療軟骨疾病（例如骨關(guān)節(jié)炎）和低骨量（例如骨質(zhì)疏松癥）和椎間盤退變的方法。在國際上，她是eLife 的高級編輯，還擔(dān)任骨科研究雜志編輯委員會的編輯顧問。 更多具體介紹請參見PI主頁：https://www.sbms.hku.hk/staff/kathryn-song-eng-cheah Post-doctoral Fellow on Mechanotransduction in Stem Cell Biology in the School of Biomedical Sciences, HKU Applications are invited for appointment as a Postdoctoral Fellow in the School of Biomedical Sciences, to commence as soon as possible for one or two years, with the possibility of renewal. Applicants should have a Ph.D. degree, preferably in Biology, Biomedical Sciences, Medical Engineering, or a related discipline. Experience in cell and molecular biology would be preferred. Applicants should also be organized, self-motivated, committed to the project schedule, and able to work independently and in a team. The appointee will participate in a multidisciplinary RGC-funded Collaborative Research Fund (CRF) project (see below) relating to the influence of the extracellular matrix on lineage-directed differentiation of human embryonic stem cells to intervertebral disc stem cells. For further information, please get in touch with Professor Kathryn Cheah (kathycheah@hku.hk) or Dr. Cheng-Han Yu (chyu1@hku.hk). The appointee will gain experience in stem cell biology, functional genomics, and single-cell biology. A highly competitive salary commensurate with qualifications and experience will be offered, in addition to annual leave and medical benefits. Project: Analyses of progenitors and differentiation trajectories in the nucleus pulposus and their relevance in intervertebral disc degeneration Intervertebral disc disease (IDD) and associated low back pain is an aging disorder of significant clinical burden. A likely disease-causing mechanism of IDD is the impairment of the reparative capacity of the intervertebral disc (IVD) tissues in the spine. The nucleus pulposus (NP) forms the central hydrated gelatinous core of the IVD. In IDD, the NP\'s mechanical strength and shock-absorbing capacity in the disc declines. But there is limited knowledge of the influence of the extracellular environment on the molecular characteristics and function of these cells in maintaining a healthy disc. In this project, we aim to study the role of extracellular matrix stiffness and mechanotransduction in NP cell differentiation and fate. Mechanical loading of the IVD is a crucial factor inducing cellular stress, matrix stiffening, and fibrosis that contribute to disc degeneration. Stiffened microenvironment can promote cell differentiation, proliferation, and expression of adhesion and ECM proteins. We will determine the impact of altering matrix stiffness after culturing in the stiffness-defined functionalized matrices on the differentiation of human embryonic stem cells to NP cells and their transcriptome and gene regulatory network. The insights will be linked and applied to the ongoing meta-analyses of genomic data on IDD. |
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kusu
新蟲 (初入文壇)
- 應(yīng)助: 0 (幼兒園)
- 金幣: 22.5
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- 在線: 1.7小時
- 蟲號: 2565960
- 注冊: 2013-07-26
- 專業(yè): 細胞增殖、生長與分化
2樓2023-04-25 14:16:03
kusu
新蟲 (初入文壇)
- 應(yīng)助: 0 (幼兒園)
- 金幣: 22.5
- 帖子: 4
- 在線: 1.7小時
- 蟲號: 2565960
- 注冊: 2013-07-26
- 專業(yè): 細胞增殖、生長與分化
3樓2023-04-26 16:34:29
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