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中國(guó)科學(xué)院生物物理研究所方顯楊研究組招聘科研助理
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課題組簡(jiǎn)介: 中國(guó)科學(xué)院生物物理研究所方顯楊課題組聚焦于RNA整合結(jié)構(gòu)生物學(xué)研究。課題組一方面致力于RNA高級(jí)結(jié)構(gòu)研究新方法的開發(fā)及其在RNA高級(jí)結(jié)構(gòu)、構(gòu)象動(dòng)態(tài)、相互作用與功能關(guān)系研究中的應(yīng)用,另一方面致力于靶向RNA與基于RNA的生物療法關(guān)鍵技術(shù)的開發(fā)。課題組近年來(lái)在利用非天然堿基系統(tǒng)發(fā)展長(zhǎng)鏈RNA的位點(diǎn)特異性標(biāo)記技術(shù)(PNAS 2020, Chem. Sci. 2020, Nat. Commun. (2021, 2023a, 2025), Biophys. J. 2022,ACS Chem. Biol. 2022, Nat. Biotechnol. 2025, )、以及應(yīng)用相關(guān)技術(shù)開展RNA的高級(jí)結(jié)構(gòu)、構(gòu)象動(dòng)態(tài)、相互作用與功能關(guān)系研究(EMBO Rep. 2019,Nat. Commun. 2020,Nat. Commun. 2021,EMBO J. 2021,Nat. Commun. (2020, 2021, 2023a, 2023b, 2024, 2025),Nucleic Acids Res. 2023)方面取得了重要進(jìn)展。 課題組的具體研究方向可見:https://ibp.cas.cn/rc/fxy/202411/t20241108_7436395.html 現(xiàn)因工作需要,擬招聘1-2名研究助理。 一、崗位職責(zé): 1. 在PI和博士后的共同指導(dǎo)下,參與相關(guān)課題的研究工作; 2. 協(xié)助課題組的相關(guān)組織管理工作。 二、招聘要求: 1. 生命科學(xué)或化學(xué)或基礎(chǔ)醫(yī)學(xué)相關(guān)專業(yè),本科或以上學(xué)歷; 2. 熟練掌握基因克隆、蛋白質(zhì)與RNA表達(dá)純化等生物化學(xué)與分子生物學(xué)實(shí)驗(yàn)技術(shù); 3. 對(duì)科學(xué)研究具有強(qiáng)烈興趣,踏實(shí)肯干,具有較強(qiáng)的動(dòng)手能力,團(tuán)隊(duì)協(xié)作精神及責(zé)任心。 三、崗位待遇: 按照中科院生物物理所的相關(guān)規(guī)定,享受中科院生物理所合同聘用制(非事業(yè)單位編制)待遇,并根據(jù)個(gè)人背景提供額外補(bǔ)助,具體待遇面議。表現(xiàn)優(yōu)秀者可推薦進(jìn)一步深造(本科生推薦碩士研究生夏令營(yíng)機(jī)會(huì),碩士生推薦普博生機(jī)會(huì))。 四、招聘方式: 應(yīng)聘者請(qǐng)于2025年12月20日前將本人詳細(xì)簡(jiǎn)歷及可以開始工作的時(shí)間通過(guò)電子郵件發(fā)至: fxy_ncrna@163.com, 并在郵件標(biāo)題注明“應(yīng)聘科研助理-本人姓名”。我們將統(tǒng)一安排面試時(shí)間。 五、課題組近期發(fā)表論文: 1. Xiaolin Niu#, Shanshan Cai#, Junzheng Wang, Chunlai Chen*, Xianyang Fang*. tRNA-dependent conformational dynamics and folding coordinate translational regulation by a full-length T-box riboswitch. Nature Communications 2025, Accepted in press. 2. Meishuo Liu#, Keyun Huang#, Jie Zhang#, Qingyang Li, Xinming Wang, Buming Gu, Hao Tang, Zhenhai Du, LiangJun Hu, Shutao Qi, Yu Ma, Hongtao Yu, Wei Xie*, Xianyang Fang*, Haifeng Wang*. CRISPR live-cell imaging reveals chromatin dynamics and enhancer interactions at multiple non-repetitive loci. Nature Biotechnology 2025, doi: 10.1038/s41587-025-02887-3. 3. Jie Zhang, Xianyang Fang*. Empowering the molecular ruler techniques with unnatural base pair system to explore conformational dynamics of flaviviral RNAs. Current Opinion in Structural Biology 2024, 89: 102944. 4. Yufan Zhang# , Zhonghe Xu# , Yu Xiao# , Haodong Jiang# , Xiaobing Zuo , Xing Li*, Xianyang Fang*. Structural mechanisms for binding and activation of a contact-quenched fluorophore by RhoBAST. Nature Communications 2024, 15(1):4206 5. Xiaolin Niu, Zhonghe Xu, Yufan Zhang, Xiaobing Zuo, Chunlai Chen*, Xianyang Fang*. Structural and dynamic mechanisms for coupled folding and tRNA recognition of a translational T-box riboswitch. Nature Communications 2023, 14(1):7394. 6. Xiang Chen#, Yan Wang#, Zhonghe Xu#, Meng-Li Cheng, Qing-Qing Ma, Rui-Ting Li, Zheng-Jian Wang, Hui Zhao, Xiaobing Zuo, Xiao-Feng Li, Xianyang Fang*, Cheng-Feng Qin*. Zika virus RNA structure controls its unique neurotropism by bipartite binding to Musashi-1. Nature Communications 2023, 14(1): 1134 7. Lilei Xu#, Yu Xiao#, Jie Zhang, Xianyang Fang*. Structural insights into translation regulation by THF-II riboswitch. Nucleic Acids Research 2023, 51(2):952-965. 8. Xianyang Fang*, Jose Gallego*, Yun-Xing Wang*. Deriving RNA topological structure from SAXS. Methods in Enzymology 2022, 677:479-529. 9. Yanping Hu#, Yan Wang#, Jaideep Singh#,Ruirui Sun#, Lilei Xu, Xiaolin Niu, Keyun Huang, Guangcan Bai, Guoquan Liu, Xiaobing Zuo, Chunlai Chen, Peter Z. Qin, Xianyang Fang*. Phosphorothioate-based posttranscriptional site-specific labeling of large RNAs for structural and dynamic studies. ACS Chemical Biology 2022, 17(9):2448-2460 10. Burkhard Endeward#, Yanping Hu#, Guangcan Bai, Guoquan Liu, Thomas F. Prisner*, Xianyang Fang*. Long-range distance determination in fully deuterated RNA with pulsed EPR spectroscopy. Biophysical Journal 2022,121(1):37-43. 11. Xiaolin Niu#, Ruirui Sun#, Zhifeng Chen, Yirong Yao, Xiaobing Zuo, Chunlai Chen*, Xianyang Fang*. Pseudoknot length modulates the folding, conformational dynamics and robustness of Xrn1 resistance of flaviviral xrRNAs. Nature Communications 2021, 12(1): 6417 12. Junfeng Ma, Xiang Cheng, Zhonghe Xu, Yikan Zhang, Jaione Valle, Shilong Fan, Xiaobing Zuo, Inigo Lasa, Xianyang Fang*. Structural mechanism for modulation of functional amyloid and biofilm formation by Staphylococcal Bap protein switch. The EMBO Journal 2021, 40(14): e107500. (Research Highlight on Nature Chemical Biology 2021, 17: 839) 13. Xiaolin Niu#, Qiuhan Liu#, Zhonghe Xu#, Zhifeng Chen, Linghui Xu, Lilei Xu, Jinghong Li*, Xianyang Fang*. Molecular mechanisms underlying the mechanical anisotropy of flaviviral exoribonuclease-resistant RNAs (xrRNAs). Nature Communications 2020, 11(1): 5496. (News and Views on Nature Chemical Biology 2021, 17: 933-934) 14. Yan Wang, Venkatesan Kathiresan, Yaoyi Chen, Yanping Hu, Wei Jiang, Guangcan Bai, Guoquan Liu, Peter Z. Qin*, Xianyang Fang*. Posttranscriptional site-directed spin labeling of large RNAs with an unnatural base pair system under non-denaturing conditions. Chemical Science 2020, 11: 9655-9664. 15. Yan Wang, Yaoyi Chen, Yanping Hu, Xianyang Fang*. Site-specific covalent labeling of large RNAs with nanoparticles empowered by expanded genetic alphabet transcription. Proceedings of the National Academy of Sciences 2020, 117(37): 22823-22832. 16. Yupeng Zhang#, Yikan Zhang#, Zhong-Yu Liu#,Meng-Li Cheng#, Junfeng Ma, Yan Wang, Cheng-Feng Qin*, Xianyang Fang*. Long non-coding subgenomic flavivirus RNAs have extended 3D structures and are flexible in solution. EMBO Reports 2019, 20(11): e47016. [ 來(lái)自版塊群 北京 ] |
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