ll_l

應(yīng)助: 0 (幼兒園)
金幣: 872.2
帖子: 170
在線: 10.3小時(shí)
蟲(chóng)號(hào): 24285650

[交流] K-CSC-生命科學(xué)博士招生

2026年倫敦國(guó)王學(xué)院csc項(xiàng)目招生啦！如果你對(duì)心臟疾病的診斷和治療感興趣，并且想研發(fā)或者拓展醫(yī)學(xué)影像mri在疾病診治中的應(yīng)用，歡迎聯(lián)系。更多詳細(xì)信息請(qǐng)見(jiàn)項(xiàng)目簡(jiǎn)介：
if you are passionate in a phd project to diagnose and treat heart disease using powerful mri and pet imaging and novel cell-based therapies come and work with us at king’s college london.
https://kcl-mrcdtp.com/project/m ... ponse-to-treatment/
https://www.kcl.ac.uk/study-lega ... hip-programme-k-csc
https://www.kcl.ac.uk/study/post ... uirements#section-3

project title: molecular imaging signatures of fibrosis to detect heart failure and response to treatment

scientific basis: heart failure (hf) affects ~1 million people in the uk (64 million in the world) and is a major driver of morbidity, mortality and nhs costs. cardiac fibrosis (cf), characterised by the excessive accumulation of collagen types 1 and 3 in the myocardium, drives hf. however, current imaging technologies do not directly measure cf, and no specific antifibrotic drugs are available. thus, developing non-invasive imaging technologies and testing the efficacy of new treatments to diagnose and treat cardiac fibrosis selectively is a largely unmet clinical need.

overarching aims: this project will use cutting-edge cardiac mri and newly developed imaging probes to non-invasively detect cardiac fibrosis and provide in vivo biomarkers to diagnose heart failure. the developed biomarkers will then be used to measure the therapeutic efficacy of clinically used and novel anti-fibrotic factors, and the effects of biological sex on therapeutic response. the project will answer the clinically important question whether molecular imaging of collagens can provide readouts for precision imaging of cardiac fibrosis to detect hearts at risk of failing, monitor and guide the development of effective therapeutics to prevent heart failure.

objectives:
1. profile the expression of collagen types 1 and 3 in cardiac fibrosis and determine whether molecular mri of these collagens quantifies cardiac fibrosis and relates to the development of hf in rodents (year 0-1).
2. utilise the developed imaging methodology to assess the therapeutic efficacy of clinically used and novel antifibrotic factors (e.g., chrdl1 and fam3c) delivered via adeno-associated vectors (year 1-2.5).
3. test whether cardiac fibrosis and the efficacy of two novel anti-fibrotic factors depend on biological sex (year 2.5-4.0).
imaging data will be complemented by tissue analysis, including histology, immunohistochemistry, gene expression, and protein immunoblotting.
techniques: animal research training; in vivo cardiac molecular mri (and pet if needed), histology and fluorescence microscopy; cell culture; pcr; western blotting; image analysis, statistics.
(e) the rotation will teach:
1) histology & microscopy. heart sections from mice with myocardial infarction will be stained with masson’s trichrome and picrosirius red (for infarct size and total collagen) and immunostained with antibodies for col1, col3, and fibroblast activation protein (fap) to detect activated fibroblasts.
2) in vivo cardiac molecular mri. the student will shadow cardiac mri scans in mice to learn how to acquire and analyse images to measure cardiac function (e.g. end-diastolic & systolic volumes, ejection fraction) and molecular imaging (area of enhancement after administration of an mri probe).

to apply you will also need a english language exam. both supervisors have excellent track record in the field and supervising students and are excited to work with enthusiastic and committed students on projects that would lead to new discoveries. if you are interested for further details please contact dr alkystis phinikaridou alkystis.1.phinikaridou@kcl.ac.uk

此項(xiàng)目適合有醫(yī)學(xué)或生物學(xué)背景的同學(xué)，期待具有動(dòng)物實(shí)驗(yàn)和基礎(chǔ)醫(yī)學(xué)實(shí)驗(yàn)技能和經(jīng)驗(yàn)的同學(xué)。有意向者歡迎發(fā)送郵件至導(dǎo)師郵箱： alkystis.1.phinikaridou@kcl.ac.uk 。如果有其他的問(wèn)題，也歡迎留言，會(huì)不定期的查看回復(fù)，如果可以的話也麻煩大家分享給適合的同學(xué)，祝大家都能找到心儀的崗位和機(jī)會(huì)。

For applications through the King’s China Scholarship scheme please contact the supervisor Dr. Alkystis Phinikaridou at alkystis.1.phinikaridou@kcl.ac.uk to discuss the project and get support on how to apply.

[ Last edited by ll_l on 2025-10-17 at 20:47 ]

回復(fù)此樓

» 猜你喜歡

材料與化工304求B區(qū)調(diào)劑已經(jīng)有5人回復(fù)
NSFC申報(bào)書(shū)里申請(qǐng)人簡(jiǎn)歷中代表性論著還需要在申報(bào)書(shū)最后的附件里面再上傳一遍嗎已經(jīng)有9人回復(fù)
一志愿北京化工大學(xué)材料與化工296分求調(diào)劑已經(jīng)有17人回復(fù)
0703化學(xué)一志愿211 總分320求調(diào)劑已經(jīng)有3人回復(fù)
0703求調(diào)劑已經(jīng)有6人回復(fù)
（081700）化學(xué)工程與技術(shù)-298分求調(diào)劑已經(jīng)有6人回復(fù)
一志愿天津大學(xué)材料與化工275求調(diào)劑已經(jīng)有22人回復(fù)
0857 資源與環(huán)境 285分已經(jīng)有6人回復(fù)
材料工程,326分，求調(diào)劑已經(jīng)有5人回復(fù)
301求調(diào)劑已經(jīng)有5人回復(fù)

» 搶金幣啦！回帖就可以得到:

查看全部散金貼

1樓 2025-10-06 15:35:55

已閱回復(fù)此樓關(guān)注TA 給TA發(fā)消息送TA紅花 TA的回帖

ll_l

新蟲(chóng) (小有名氣)

應(yīng)助: 0 (幼兒園)
金幣: 872.2
帖子: 170
在線: 10.3小時(shí)
蟲(chóng)號(hào): 24285650

For applications through the King’s China Scholarship scheme please contact the supervisor Dr. Alkystis Phinikaridou at alkystis.1.phinikaridou@kcl.ac.uk to discuss the project and get support on how to apply.

贊一下

回復(fù)此樓

12樓2025-10-17 20:46:50

已閱回復(fù)此樓關(guān)注TA 給TA發(fā)消息送TA紅花 TA的回帖

簡(jiǎn)單回復(fù)

tfang2樓

2025-10-06 15:51 回復(fù)

ll_l(金幣+1): 謝謝參與

發(fā)自小木蟲(chóng)手機(jī)客戶端

tzynew3樓

2025-10-06 15:54 回復(fù)

ll_l(金幣+1): 謝謝參與

k 發(fā)自小木蟲(chóng)手機(jī)客戶端

laozhu55724樓

2025-10-06 16:27 回復(fù)

ll_l(金幣+1): 謝謝參與

xiaoqiuqiu205樓

2025-10-06 16:34 回復(fù)

ll_l(金幣+1): 謝謝參與

shenrenren6樓

2025-10-06 16:39 回復(fù)

ll_l(金幣+1): 謝謝參與

XG-WUST7樓

2025-10-06 17:29 回復(fù)

ll_l(金幣+1): 謝謝參與

up 發(fā)自小木蟲(chóng)IOS客戶端

nono20098樓

2025-10-06 19:27 回復(fù)

ll_l(金幣+1): 謝謝參與

kingluck9樓

2025-10-06 20:20 回復(fù)

ll_l(金幣+1): 謝謝參與

s9659z10樓

2025-10-06 22:21 回復(fù)

ll_l(金幣+1): 謝謝參與

lymjjh11樓

2025-10-06 22:41 回復(fù)

ll_l(金幣+1): 謝謝參與

最具人氣熱帖推薦 [查看全部]	作者	回/看	最后發(fā)表

[考研] 一志愿北京化工大學(xué)材料與化工296分求調(diào)劑 +15	稻妻小編 2026-03-09	17/850	2026-03-11 22:45 by 2020015
[考研] 334求調(diào)劑 +3	mjqzz 2026-03-06	3/150	2026-03-11 20:38 by 清風(fēng)月
[考研] 一志愿安徽大學(xué)材料工程專碩313分，求調(diào)劑的學(xué)校 +7	Yu先生 2026-03-10	9/450	2026-03-11 16:46 by 2020015
[考研] 293求調(diào)劑，一志愿陜師大生物學(xué) +3	??????.?.??? 2026-03-09	3/150	2026-03-11 10:02 by 學(xué)員8dgXkO
[考研] 化工0817調(diào)劑 +8	燦若星晨 2026-03-10	8/400	2026-03-10 22:44 by 星空星月
[考研] 327求調(diào)劑 +3	Ffff03 2026-03-10	3/150	2026-03-10 22:30 by macy2011
[考研] 收調(diào)劑 +7	調(diào)劑的考研學(xué)生 2026-03-10	7/350	2026-03-10 17:57 by 麥茶湯圓
[考研] 一志愿湖師大化學(xué)289求調(diào)劑 +5	XMCMM3.14159 2026-03-10	5/250	2026-03-10 15:41 by shangxh
[考研] 材料專碩調(diào)劑 +7	慕辰123 2026-03-05	10/500	2026-03-10 14:22 by peike
[考研] 材料與化工一志愿山大 321分求調(diào)劑 +6	每天散步 2026-03-09	7/350	2026-03-10 10:52 by 星空星月
[碩博家園] 木蟲(chóng)好像不熱鬧了，是不是？ +4	偏振片 2026-03-10	4/200	2026-03-10 09:51 by longwave
[考研] 320求調(diào)劑 +4	魏zy 2026-03-08	4/200	2026-03-09 16:14 by ruiyingmiao
[考研] 0832食品科學(xué)與工程293調(diào)劑 +3	東東不東 2026-03-07	3/150	2026-03-09 15:58 by ls_13456
[考研] 考研調(diào)劑，一志愿山東大學(xué)材料與化工，328分，政治51 +5	關(guān)你西紅柿929 2026-03-08	6/300	2026-03-09 13:50 by 新篇章DFSS
[考研] 化學(xué)工程與技術(shù)316求調(diào)劑 +7	Sixuan wang 2026-03-06	7/350	2026-03-08 11:23 by 我的船我的海
[考研] 085701環(huán)境工程317分求調(diào)劑 +9	6汆尼9 2026-03-07	9/450	2026-03-08 06:41 by 劉兵
[考研] 276求調(diào)劑本科天津工業(yè)大學(xué) 一志愿北京化工大學(xué)0855 +4	路lyh123 2026-03-06	6/300	2026-03-07 11:37 by shdliugang
[考研] 085600材料與化工 292分求調(diào)劑 +6	程晴之 2026-03-06	6/300	2026-03-07 09:22 by 斬魂滴兔子！
[考研] 復(fù)試調(diào)劑 +7	呼呼？~+123456 2026-03-05	10/500	2026-03-06 16:07 by @颯颯颯颯
[考研] 材料與化工354調(diào)劑 +4	Lucy-xiao 2026-03-06	7/350	2026-03-06 09:57 by hxuq8429