 |
 |
 |
 |
 |
 |
||
 |
 |
 |
 |
 |
| 1 | 1/1 | 返回列表 |
| 查看: 470 | 回復: 0 | |||||||||||
| 【有獎交流】積極回復本帖子，參與交流，就有機會分得作者 努力打工的打工?的 5 個金幣 | |||||||||||
[交流]
計算生物、化學、生物信息、結(jié)構(gòu)生物學方向
|
|||||||||||
一、aidd/cadd scientist→leader-上海 responsibilities: 1. support/drive early discovery projects from target identification/evaluation to hit identification, to lead optimization, and all the way to pcc and ind-enabling studies 2. contribute to the hit/lead optimization campaigns through mitigating any detected liabilities in terms of potency, selectivity, and adme/pk profiles 3. contribute to the global ai platform in optimizing current tools or establishing novel ai/machine learning models in cheminformatics and/or molecular modeling areas, which are applicable to discovery projects 4. proactively integrate experimental data and apply computational approaches to generate knowledge and insights requirements: 1. phd in computational chemistry/ biology, cadd, or any relevant areas that also bring the following set of skills and expertise 2. proficient in structure-/ligand-based drug design, including molecular docking, virtual screening, qsar, homology modeling, molecular dynamics, and quantum mechanics, etc., and master the relevant tools, including schrodinger, moe, discovery studio, etc. 3. proficient command of at least one programming language (python, c, c++, perl, shell, …) 4. highly motivated, possess excellent communication skills, enjoy working in multidisciplinary teams and are fluent in english 5. experience in ai/machine learning, data mining, and automate workflows is a plus 6. experience in the pharmaceutical industry or postdoctoral research in the drug discovery context would be a plus 7. good understanding of drug discovery principles including the fundamentals of medicinal chemistry, adme/pk and disease biology is a big plus 8. a track record of scientific contributions illustrated by publications and/or patents. extra points 1.expertise in machine learning (ml) and deep learning (dl), with experience in developingor applying ml/dl methods in at least one of the following fields: molecular propertyprediction, molecular generation, retrosynthesis prediction, protein design, biomedical textmining, or bioinformatics analysis, etc 2.experience in antibody and peptide generation or small molecule drug design for ppi would be a big plus. 二、抗體設計-北京 主要工作職責： 1.基于蛋白質(zhì)結(jié)構(gòu)分析和預測，抗原抗體對接等手段，設計點突變或者文庫，從多個維度優(yōu)化抗體藥物的特性，篩選有治療潛力的分子； 2.抗體人源化，親和力成熟，穩(wěn)定性優(yōu)化，雙特異抗體的設計等； 3.完成分子克隆的構(gòu)建，和團隊一起驗證蛋白質(zhì)優(yōu)化的設計； 4.及時分析匯報數(shù)據(jù)，幫助項目組做決定； 主要交付結(jié)果 1.作為治療性抗體發(fā)現(xiàn)團隊的一員，完成抗體藥物的優(yōu)化設計并最終交付pcc分子； 2.獨立完成蛋白藥物的設計和相應的克隆表達工作； 3.按時交付結(jié)果； 任職資格 教育和工作背景: 1.蛋白設計，結(jié)構(gòu)生物學相關(guān)領(lǐng)域博士以上學歷， 2年以上工作經(jīng)驗； 2.深入了解蛋白結(jié)構(gòu)和功能，精通一個或多個常用的蛋白質(zhì)工程分子建模軟件包 （schrodinger, rosetta, moe, discovery studio）； 3.有蛋白質(zhì)工程化改造的研究經(jīng)驗，如提高穩(wěn)定性，抗體人源化，親和力成熟，雙特異抗體設計等； 4.熟練掌握分子生物學技術(shù)，蛋白表達純化技術(shù)。 5.有雙抗/多抗設計經(jīng)驗者優(yōu)先考慮 投遞請標注：XX崗位+姓名+畢業(yè)院校+最高學位 KSX0928 charich.yp@x-giants.com [ 來自版塊群 上海 ] |
回復此樓» 猜你喜歡
一志愿天津大學材料與化工275求調(diào)劑
已經(jīng)有20人回復
-
274求調(diào)劑0856材料化工
已經(jīng)有8人回復
-
泣血叩求調(diào)劑恩，愿以丹心報師恩
已經(jīng)有5人回復
-
274環(huán)境工程求調(diào)劑
已經(jīng)有8人回復
-
289求調(diào)劑
已經(jīng)有3人回復
-
271求調(diào)劑
已經(jīng)有4人回復
-
311求調(diào)劑
已經(jīng)有6人回復
-
0856化工原理
已經(jīng)有3人回復
-
291分獸醫(yī)專碩 一志愿華中農(nóng)
已經(jīng)有3人回復
-
工科0856專碩化學工程269能調(diào)劑嗎
已經(jīng)有8人回復
相關(guān)版塊跳轉(zhuǎn)
我要訂閱樓主 努力打工的打工?/a> 的主題更新
| 1 | 1/1 | 返回列表 |
| 最具人氣熱帖推薦 [查看全部] | 作者 | 回/看 | 最后發(fā)表 | |
|---|---|---|---|---|
|
[考研]
一志愿天津大學材料與化工275求調(diào)劑
 10+5
|
穿只靴子 2026-03-07 | 20/1000 |
|
|---|---|---|---|---|
|
[考研] 材料專碩288分求調(diào)劑 一志愿211 +3 | 在家想你 2026-03-11 | 3/150 |
|
|
|
[考研] 265求調(diào)劑 +8 | 小木蟲085600 2026-03-09 | 11/550 |
|
|
|
[考研] 歡迎211本科同學，過A區(qū)國家線，A區(qū)非偏遠一本，交叉學科課題組 +23 | lisimayy 2026-03-04 | 37/1850 |
|
|
|
[考研] 332材料求調(diào)劑 +6 | zjy101327 2026-03-05 | 8/400 |
|
|
|
[考研] 2026考研求調(diào)劑-材料類-本科211一志愿985-初試301分 +10 | 蟲友233 2026-03-07 | 10/500 |
|
|
|
[考研] 311求調(diào)劑 +3 | 牛乳糖的卡卡 2026-03-10 | 3/150 |
|
|
|
[考研] 0856材料與化工309分求調(diào)劑 +4 | ZyZy…… 2026-03-10 | 4/200 |
|
|
|
[考研] 材料與化工求調(diào)劑 +11 | 與冬清寧 2026-03-07 | 14/700 |
|
|
|
[考研] 研究生招生 +3 | 徐海濤11 2026-03-10 | 6/300 |
|
|
|
[考研] 085701環(huán)境工程295求調(diào)劑，一志愿A區(qū)211 +8 | 等春來， 2026-03-06 | 9/450 |
|
|
|
[考研] 一志愿山東大學，總分327，英語二79，有論文，有競賽，已過四六級 +3 | 木木目目1 2026-03-09 | 3/150 |
|
|
|
[考研] 310 070300化學求調(diào)劑 +4 | 撲風鈴的貓 2026-03-08 | 5/250 |
|
|
|
[考研] 0832食品科學與工程293調(diào)劑 +3 | 東東不東 2026-03-07 | 3/150 |
|
|
|
[考研] 中科大材料299求調(diào)劑 +10 | DAIjiayo 2026-03-05 | 16/800 |
|
|
|
[考研] 083000環(huán)境科學與工程調(diào)劑 +5 | 加油呀fxy 2026-03-07 | 6/300 |
|
|
|
[考研] 求調(diào)劑 +3 | 拾柒12。 2026-03-08 | 3/150 |
|
|
|
[考研] 一志愿鄭大071000分數(shù)282求調(diào)劑 +3 | 研研顏 2026-03-05 | 7/350 |
|
|
|
[考研] 不限學校專業(yè)的調(diào)劑同學看過來 +5 | 啊擺啊擺 2026-03-05 | 9/450 |
|
|
|
[考研] 材料調(diào)劑 +5 | ws 上岸鴨 2026-03-05 | 5/250 |
|