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yexuqing木蟲(chóng)之王 (文學(xué)泰斗)
太陽(yáng)系系主任
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[交流]
Evolution of interorganismal strigolactone biosynthesis in seed plants
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Evolution of interorganismal strigolactone biosynthesis in seed plants 種子植物間獨(dú)角麥內(nèi)酯生物合成的進(jìn)化 ▲ 作者：ANQI ZHOU, ANNALISE KANE, SHENG WU, KAIBIAO WANG, MICHELL SANTIAGO, YUI ISHIGURO, KAORI YONEYAMA, MALATHY PALAYAM, NITZAN SHABEK, AND YANRAN LI ▲鏈接： https://www.science.org/doi/10.1126/science.adp0779 ▲摘要： 己糖內(nèi)酯（SLs）是一種小的信號(hào)分子，參與與其他植物和土壤微生物的信號(hào)傳遞，并參與植物的生長(zhǎng)發(fā)育。雖然對(duì)SL的功能作用已經(jīng)有了很好的描述，但對(duì)種子植物中SL生物合成的進(jìn)化卻知之甚少。研究者利用合成生物學(xué)方法鑒定了細(xì)胞色素P450酶CYP722C的功能，該酶催化卡拉內(nèi)酯酸（CLA）轉(zhuǎn)化為標(biāo)準(zhǔn)SLs的關(guān)鍵步驟。 CYP722A是CYP722C的進(jìn)化前身，可將CLA轉(zhuǎn)化為非規(guī)范的SL-16-羥基CLA，主要存在于莖中，并參與控制莖的分支。16-羥基cla通過(guò)兩種酶轉(zhuǎn)化為其他可能的生物活性形式的SLs，因此CYP722A的生物合成被認(rèn)為是典型SLs進(jìn)化的關(guān)鍵步驟。 ▲ Abstract： Strigolactones (SLs) are small signaling molecules that are involved in signaling with other plants and soil microbes and in plant growth and development. Although the functional roles of SLs are well characterized, less is known about the evolution of SL biosynthesis in seed plants. Zhou et al. leveraged a synthetic biology approach to identify the function of a cytochrome P450 enzyme, CYP722C, that catalyzes a critical step in the conversion of carlactonoic acid (CLA) to canonical SLs. CYP722A, an evolutionary predecessor of CYP722C, converts CLA into a noncanonical SL, 16-hydroxy-CLA, that is primarily detected in shoots and involved in control of shoot branching. 16-hydroxy-CLA is converted to other likely bioactive forms of SLs by two enzymes, so its biosynthesis by CYP722A is proposed to be a critical step in the evolution of canonical SLs. 氣候Climate |
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