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yexuqing木蟲之王 (文學泰斗)
太陽系系主任
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[交流]
A panoramic view of cell population dynamics in mammalian aging
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A panoramic view of cell population dynamics in mammalian aging 哺乳動物衰老過程中細胞種群動態(tài)的全景視圖 ▲ 作者:ZEHAO ZHANG, CHLOE SCHAEFER, WEIRONG JIANG, ZIYU LU, JASPER LEE, ANDRAS SZIRAKI, ABDULRAOUF ABDULRAOUF, BRITTNEY WICK, MAXIMILIAN HAEUSSLER, AND JUNYUE CAO ▲鏈接: https://www.science.org/doi/10.1126/science.adn3949 ▲摘要: 衰老是一個復雜的過程,導致組織和細胞類型的功能變化。利用單核RNA測序,這些變化開始被記錄在整個生物體的生命周期中。Zhang等人在一種常用的小鼠品系和兩種免疫缺陷品系及其野生型對應品系中生成了跨越多個時間點的細胞圖譜,并對這些時間點上細胞群體的變化和細胞類型內(nèi)表達的變化進行了分類。 在研究免疫補體減少的作用時,作者發(fā)現(xiàn),在缺乏這些成年淋巴細胞的情況下,某些腸上皮細胞數(shù)量增加。這項研究為研究衰老的研究人員提供了資源,特別是在免疫缺陷的背景下。 ▲ Abstract: Aging is a complex process that results in functional changes across tissues and cell types. These changes are beginning to be documented across organismal lifespans using single-nuclei RNA sequencing. Zhang et al. generated cell atlases across multiple time points in both a commonly used mouse strain and two immunodeficient strains and their wild-type counterparts, cataloging changes in cell populations and expression changes within cell types over these time points. Investigating the role of a diminished immune complement, the authors found that certain intestinal epithelial populations increased in the absence of these adult lymphocytes. This study provides a resource for researchers studying aging, particularly in the context of immunodeficiency. |

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