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斜月彡星主管區(qū)長 (文學(xué)泰斗)
噢,不是煙鬼丶
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[求助]
siRNA 序列中反向脫氧核苷酸 invdN 什么意思 已有1人參與
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有些專利里會出現(xiàn)類似術(shù)語,是屬于修飾還是什么?最好有參考文獻(xiàn)或來源,謝謝!![]() ![]() 如:3′至3′鍵(反向)核苷酸 invdN、invN、invn、invAb |

木蟲之王 (文壇精英)
我愛打老虎
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應(yīng)該都屬于修飾,invAb可以檢索出來是 inverted abasic deoxyribonucleotide的縮寫。 文獻(xiàn)參考:siRNA modification and delivery for drug development https://www.cell.com/trends/mole ... 471-4914(22)00204-0 |

主管區(qū)長 (文學(xué)泰斗)
噢,不是煙鬼丶
![]() |
專家經(jīng)驗(yàn): +239 |

木蟲之王 (文壇精英)
我愛打老虎

木蟲之王 (文壇精英)
我愛打老虎
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另外,可以看看Oligo合成廠家的介紹。 https://www.genelink.com/newsite/products/modoligosINFO.asp Inverted 2'O methyl A (reverse linkage) [Inv-mA] 27-6447A $202.00 $202.00 $448.00 $741.00 Inquire $3,586.00 $4,482.00 Inverted 2'O methyl C (reverse linkage) [Inv-mC] 27-6447C $202.00 $202.00 $448.00 $741.00 Inquire $3,586.00 $4,482.00 Inverted 2'O methyl G (reverse linkage) [Inv-mG] 27-6447G $202.00 $202.00 $448.00 $741.00 Inquire $3,586.00 $4,482.00 Inverted 2'O methyl mixed bases (reverse linkage) [Inv-mN] 27-6447N $202.00 $202.00 $448.00 $741.00 Inquire $3,586.00 $4,482.00 Inverted 2'O methyl U (reverse linkage) [Inv-mU] 27-6447U $202.00 $202.00 $448.00 $741.00 Inquire $3,586.00 $4,482.00 Inverted Abasic Site (dSpacer abasic furan) [iB] 26-6448 $200.00 $200.00 $255.00 $321.00 $1,147.50 $1,582.00 $1,809.00 Inverted dA (reverse linkage) [Inv-dA] 26-6551 $45.00 $45.00 $59.00 $88.00 $265.50 $472.00 $590.00 Inverted dC (reverse linkage) [Inv-dC] 26-6552 $45.00 $45.00 $59.00 $88.00 $265.50 $472.00 $590.00 Inverted dG (reverse linkage) [Inv-dG] 26-6553 $45.00 $45.00 $59.00 $88.00 $265.50 $472.00 $590.00 Inverted dT (reverse linkage) [Inv-dT] 26-6554 $45.00 $45.00 $59.00 $88.00 $265.50 $472.00 $590.00 Inverted rA (reverse linkage) [Inv-rA] 27-6441 $202.00 $202.00 $448.00 $741.00 $2,016.00 $3,586.00 $4,482.00 Inverted rC (reverse linkage) [Inv-rC] 27-6442 $202.00 $202.00 $448.00 $741.00 $2,016.00 $3,586.00 $4,482.00 Inverted rG (reverse linkage) [Inv-rG] 27-6443 $202.00 $202.00 $448.00 $741.00 $2,016.00 $3,586.00 $4,482.00 Inverted rU (reverse linkage) [Inv-rU] 27-6444 $202.00 $202.00 $448.00 $741.00 $2,016.00 $3,586.00 $4,482.00 |

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