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woshicaiji新蟲 (初入文壇)
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Call for 2024 Chinese Applicants Running for a CSC Fellowship
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Call for 2024 Chinese Applicants Running for a CSC Fellowship : IMDEA Nanoscience (https://www.nanociencia.imdea.org/) Systems Chemistry Laboratory (www.hermanslab.com) Supervising scientist: Professor Thomas M. HERMANS (Thomas.hermans@imdea.org) Research Field: Out-of-equilibrium supramolecular self-assembly Keywords: Systems Chemistry, Self-assembly, Nonequilibrium systems, Supramolecular polymers Research Area: Looking at nature, we see that living materials with biological functionality, such as the actin or microtubule (MT) cytoskeletal network, achieve dynamics as well as supramolecular structures with the same protein building blocks. In other words, the components can assemble, but also react (i.e., tubulin is also an enzyme that hydrolyses guanosine triphosphate GTP), which in turn affects the assemblies. In this way, living systems use chemical fuels (e.g., GTP) and self-assembly to create a built-in chemomechanical interaction. Moreover, such networks operate in sustained out-of-equilibrium states at the onset of oscillations,1–3 which results in rapid response and adaptivity. We have recently shown 4–5 reaction cycles in solution and gels, where interesting new behaviors were found, such as supramolecular size oscillations, traveling polymerization, or transient disassembly. We hope such reaction cycles form the basis of new life-like materials where material properties are fuel (and waste) dependent. The PhD project involves the synthesis of new microtubule like structures based on all artificial small molecules that can be controlled by chemical fuels and/or light. References： 1. Obermann, H., Mandelkow, E. M., Lange, G. & Mandelkow, E. Microtubule oscillations. Role of nucleation and microtubule number concentration. Journal of Biological Chemistry 265, 4382–4388 (1990). 2. Valiron, O., Caudron, N. & Job, D. Microtubule dynamics. Cellular and Molecular Life Sciences CMLS 58, 2069–2084 (2001). 3. Westendorf, C. et al. Actin cytoskeleton of chemotactic amoebae operates close to the onset of oscillations. Proceedings of the National Academy of Sciences 110, 3853–3858 (2013). 4. Singh, N., Lainer, B., Formon, G. J. M., De Piccoli, S. & Hermans, T. M. Re-programming Hydrogel Properties Using a Fuel-Driven Reaction Cycle. J. Am. Chem. Soc. 142, 4083–4087 (2020). 5. Leira-Iglesias, J., Tassoni, A., Adachi, T., Stich, M. & Hermans, T. M. Oscillations, travelling fronts and patterns in a supramolecular system. Nature Nanotechnology 13, 1021 (2018). Requirements: • Experience in Supramolecular Chemistry or Crystallizations • Knowledge of chemical kinetics • Knowledge of confocal and/or superresolution microscopy is a bonus Work Place: IMDEA Nanoscience is a leading institute at the interface of chemistry, physics, and biology. It houses the top groups in supramolecular chemistry of the greater Madrid area. Being the capital of Spain, Madrid has a network of top rated universities and research institutes, great weather and food, and excellent research and life quality. Earliest Start: 01.09.2024 Project duration: 48 months Language Requirement: English B2 |
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