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K-CSC-生命科學(xué)博士招生
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2026年倫敦國王學(xué)院csc項目招生啦！如果你對心臟疾病的診斷和治療感興趣，并且想研發(fā)或者拓展醫(yī)學(xué)影像mri在疾病診治中的應(yīng)用，歡迎聯(lián)系。更多詳細(xì)信息請見項目簡介： if you are passionate in a phd project to diagnose and treat heart disease using powerful mri and pet imaging and novel cell-based therapies come and work with us at king’s college london. https://kcl-mrcdtp.com/project/m ... ponse-to-treatment/ https://www.kcl.ac.uk/study-lega ... hip-programme-k-csc https://www.kcl.ac.uk/study/post ... uirements#section-3 project title: molecular imaging signatures of fibrosis to detect heart failure and response to treatment scientific basis: heart failure (hf) affects ~1 million people in the uk (64 million in the world) and is a major driver of morbidity, mortality and nhs costs. cardiac fibrosis (cf), characterised by the excessive accumulation of collagen types 1 and 3 in the myocardium, drives hf. however, current imaging technologies do not directly measure cf, and no specific antifibrotic drugs are available. thus, developing non-invasive imaging technologies and testing the efficacy of new treatments to diagnose and treat cardiac fibrosis selectively is a largely unmet clinical need. overarching aims: this project will use cutting-edge cardiac mri and newly developed imaging probes to non-invasively detect cardiac fibrosis and provide in vivo biomarkers to diagnose heart failure. the developed biomarkers will then be used to measure the therapeutic efficacy of clinically used and novel anti-fibrotic factors, and the effects of biological sex on therapeutic response. the project will answer the clinically important question whether molecular imaging of collagens can provide readouts for precision imaging of cardiac fibrosis to detect hearts at risk of failing, monitor and guide the development of effective therapeutics to prevent heart failure. objectives: 1. profile the expression of collagen types 1 and 3 in cardiac fibrosis and determine whether molecular mri of these collagens quantifies cardiac fibrosis and relates to the development of hf in rodents (year 0-1). 2. utilise the developed imaging methodology to assess the therapeutic efficacy of clinically used and novel antifibrotic factors (e.g., chrdl1 and fam3c) delivered via adeno-associated vectors (year 1-2.5). 3. test whether cardiac fibrosis and the efficacy of two novel anti-fibrotic factors depend on biological sex (year 2.5-4.0). imaging data will be complemented by tissue analysis, including histology, immunohistochemistry, gene expression, and protein immunoblotting. techniques: animal research training; in vivo cardiac molecular mri (and pet if needed), histology and fluorescence microscopy; cell culture; pcr; western blotting; image analysis, statistics. (e) the rotation will teach: 1) histology & microscopy. heart sections from mice with myocardial infarction will be stained with masson’s trichrome and picrosirius red (for infarct size and total collagen) and immunostained with antibodies for col1, col3, and fibroblast activation protein (fap) to detect activated fibroblasts. 2) in vivo cardiac molecular mri. the student will shadow cardiac mri scans in mice to learn how to acquire and analyse images to measure cardiac function (e.g. end-diastolic & systolic volumes, ejection fraction) and molecular imaging (area of enhancement after administration of an mri probe). to apply you will also need a english language exam. both supervisors have excellent track record in the field and supervising students and are excited to work with enthusiastic and committed students on projects that would lead to new discoveries. if you are interested for further details please contact dr alkystis phinikaridou alkystis.1.phinikaridou@kcl.ac.uk 此項目適合有醫(yī)學(xué)或生物學(xué)背景的同學(xué)，期待具有動物實驗和基礎(chǔ)醫(yī)學(xué)實驗技能和經(jīng)驗的同學(xué)。有意向者歡迎發(fā)送郵件至導(dǎo)師郵箱： alkystis.1.phinikaridou@kcl.ac.uk 。如果有其他的問題，也歡迎留言，會不定期的查看回復(fù)，如果可以的話也麻煩大家分享給適合的同學(xué)， 祝大家都能找到心儀的崗位和機(jī)會。 For applications through the King’s China Scholarship scheme please contact the supervisor Dr. Alkystis Phinikaridou at alkystis.1.phinikaridou@kcl.ac.uk to discuss the project and get support on how to apply. [ Last edited by ll_l on 2025-10-17 at 20:47 ] |
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