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關(guān)于硫酸角質(zhì)素抗體的簡介
又稱硫酸角質(zhì),與蛋白質(zhì)形成結(jié)合體存在于哺乳類的角膜、椎間板、軟骨和動脈中,也就是以蛋白多糖(proteoglgcan)形式存在的一種粘多糖。在多數(shù)情況下和硫酸軟骨素共存,也有時兩者只有一個蛋白質(zhì)部分。在胎兒期軟骨的蛋白多糖中幾乎不含有硫酸角質(zhì)素,但隨著年齡增加其含量漸增,這可作為動物結(jié)締組織伴隨年齡發(fā)生變化的例證。硫酸角質(zhì)素是以D-半乳糖和N-乙酰葡糖胺-6-硫酸形成的雙糖作為主要重復單位,一部分半乳糖在6位上被硫酸化或分枝成別的糖鏈。有的硫酸角質(zhì)素也含有少量巖藻糖,硅鋁酸,這種細微的不均一的結(jié)構(gòu),是組織上的特異性。從與蛋白質(zhì)結(jié)合的形式上來看,在角膜的硫酸角質(zhì)素是N-乙酰葡糖胺和天門冬氨酸以N-糖苷鍵相結(jié)合,而軟骨等骨骼系統(tǒng)的硫酸角質(zhì)素是N-乙酰葡糖胺和絲氨酸、蛋氨酸以 O-糖苷鍵相結(jié)合而彼此不同。不論哪一種情況,在結(jié)合區(qū)附近,均尚有數(shù)分子甘露糖存在。
硫酸角質(zhì)素抗體
Catalyzes the transfer of sulfate to position 6 of galactose residues of keratan. It has a preference for sulfating keratan sulfate, but it also transfers sulfate to the unsulfated polymer. The sulfotransferase activity on sialyl LacNAc structures is much higher than the corresponding desialylated substrate, and only internal galactose residues are sulfated. It also may function in the sulfation of sialyl N-acetyllactosamine oligosaccharide chains attached to glycoproteins. It participates in biosynthesis of selectin ligands. Selectin ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Aggrecan is the major proteoglycan of human articular cartilage. The core protein is substituted by a number of keratan sulfate and chondroitin sulfate glycosaminoglycan chains. Whereas chondroitin sulfate is widely distributed throughout the body, keratan sulfate is primarily expressed in cartilage (joints, trachea, intervertebral discs) and cornea.
作者:畢合生物
公眾號:畢合生物
畢合生物提供服務內(nèi)容:分子生物學、免疫, 重組蛋白及ELISA相關(guān)、活性小分子化合物、高端化學、材料化學、細胞資源庫與培養(yǎng)相關(guān)、生命科學、天然產(chǎn)物 |
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