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小木蟲論壇-學術科研互動平臺 » 生物醫(yī)藥區(qū) » 藥學 » 中藥學 » 求助各位大佬一篇付費文獻
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求助各位大佬一篇付費文獻
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Exenatide-loaded microsphere/ thermosensitive hydrogel long-acting delivery system with high drug bioactivity 作者:Wang, PX (Wang, Puxiu) [1] ; Zhuo, XZ (Zhuo, Xuezhi) [1] ; Chu, W (Chu, Wei) [1] ; Tang, X (Tang, Xing) [1] 卷528 期1-2 頁62-75 DOI10.1016/j.ijpharm.2017.05.069 出版時間AUG 7 2017 已索引2017-08-07 文獻類型Article 摘要 A series of mixed hydrogels of PLGA-PEG-PLGA and PCLA-PEG-PCLA were synthesized, and investigated in terms of their critical micelle concentration, stability and thermosensitive properties. Also, some mixed hydrogel was selected to prepare Depot-gel-in-Ms-in-Matrix-gel system for the treatment of type 2 diabetes mellitus. Briefly, Exenatide (EXT) loaded hydrogels was encapsulated in PLGA microspheres (Ms) and further encapsulated into blank hydrogel. The mechanism of Exenatide release involved drug diffusion, hydrogel diffusion, PLGA erosion and mixed hydrogel erosion. The results showed that EXT release in vitro was at a sustained rate for 46 days, because it is controlled by the inner-deport-gel, the Ms matrix and the outer-Matrix-gel successively. No burst release or platform was observed due to the interception function and control function of the outer-Matrix-gel. The biological activity of EXT was protected, because the hydrophilic EXT molecules tend to distribute in the hydrophilic domain of the mixed hydrogel. In vivo, a single injection of Depot-gel-in-Ms-in-Matrix-gel allowed mice to maintain a stable blood glucose concentration and well-controlled body weight for 20 days. In addition, results of oral glucose tolerance test and Hematoxylin-Eosin staining demonstrated that triple-barrier Depot-gelin-Ms-in-Matrix-gel was a promising hydrophilic protein/polypeptide-loaded long-acting system with high drug bioactivity. (C) 2017 Elsevier B.V. All rights reserved. 關鍵詞 作者關鍵詞ExenatidePeptideHydrogelPLGA microspheresPolymeric micelles Keywords PlusPCLA-PEG-PCLABIODEGRADABLE TRIBLOCK COPOLYMERTYPE-2 DIABETES-MELLITUSCONTROLLED-RELEASEPLGA MICROSPHERESMOLECULAR-WEIGHTPOLYMERIC NANOPARTICLESBIOMEDICAL APPLICATIONSDEGRADATION PROPERTIESINTRAVITREAL DELIVERY 作者信息 通訊作者地址 Tang, Xing (通訊作者) Shenyang Pharmaceut Univ, Coll Pharm, Dept Pharmaceut, Shenyang 10016, Liaoning, Peoples R China 地址 1 Shenyang Pharmaceut Univ, Coll Pharm, Dept Pharmaceut, Shenyang 10016, Liaoning, Peoples R China 電子郵件地址tanglab@126.com 類別/分類 研究方向Pharmacology & Pharmacy 引文主題 2 Chemistry 2.53 Polymers & Macromolecules 2.53.371 Hydrogels |
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zyqchem
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2樓2023-02-24 21:16:50
3樓2023-02-25 15:29:07
zyqchem
木蟲之王 (文學泰斗)
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4樓2023-02-25 15:57:46
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