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[交流]
美國Wayne State University化學(xué)系講席教授Hien M Nguyen課題組招聘博士后
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招聘明細(xì) position details postdoctoral positions in synthesis of oligosaccharides and sulfate oligosaccharides at wayne state university, detroit, michigan two postdoctoral positions are available in the laboratory of professor hien nguyen in the department of chemistry at wayne state university for candidates with expertise in the chemical synthesis of oligosaccharides and sulfated oligosaccharides. the goals of the project are (1) to prepare panels of oligosaccharides to examine their capacity as vaccine adjuvants; (2) to prepare panels of sulfated oligosaccharides to examine their ability as potent inhibitors of heparanase and sars-cov-2 spike protein as well as to evaluate their ability to prevent p-tau-elicited neurotoxicity for potential treatment of alzheimer’s disease. the ultimate aim is to develop carbohydrate-based therapeutics for various diseases. position requirements （其實有較好的合成經(jīng)驗就可以了，發(fā)送簡歷吧） ph.d. degree in organic chemistry, chemical biology, or medicinal chemistry with extensive experience in organic synthesis and/or carbohydrate synthesis, including an ability to identify target carbohydrates of biological importance as well as to design and employ chemical syntheses to obtain these compounds. experience with various spectroscopic technologies including nmr and mass spectrometry for organic compounds characterization is essential. expertise in binding assays is also essential. interested candidates should contact: professor hien nguyen department of chemistry wayne state university 5101 cass avenue detroit, mi 48202, usa hmnguyen@wayne.edu 課題組簡介： hien m nguyen carl johnson/pfizer professor of organic chemistry, wayne state university hien m nguyen, wayne state university 講席教授。1996年本科畢業(yè)于tufts university, 導(dǎo)師為marc d’alarco教授，2003年博士畢業(yè)于university of illinois at urbana-champaign，師從david gin教授。2003 ╟ 2006年在stanford university進(jìn)行博士后研究，導(dǎo)師為barry trost教授。nguyen教授2009年加入university of iowa，并于2013年獲得終身教職，升任副教授。2018年，nguyen教授以carl johnson professor of chemistry講習(xí)教授身份加入wayne state university化學(xué)系，工作至今。nguyen教授已經(jīng)在j. am. chem. soc., angew. chem. int. ed., chem. sci.,acs cata. 等權(quán)威雜志上發(fā)表文章，并獲得多個獎項。課題組研究條件一流，經(jīng)費充足，目前以pi身份主持nih在研項目4項。 課題組鏈接： https://s.wayne.edu/nguyengroup/ 研究方向 the research program in the laboratory of professor nguyen lies at the crossroads of organic chemistry, chemical biology, organocatalysis, and transition-metal catalysis. the broad goals of our group are (1) to design and synthesize sulfated oligosaccharides and multivalent carbohydrate molecules (glycopolymers) as potent inhibitors of heparanase for treatment of cancers; (2) to design and synthesize heparan sulfate-like oligosaccharides and glycopolymers to inhibit sars-cov-2 virus-cell entry, thereby inhibiting progeny virus release from infected cell and spread; (3) to study saponin molecules as novel vaccine adjuvants for use in humans to combat a range of infectious diseases; (4) to develop carbohydrate molecules to control of hyperphosphorylated tau-mediated cell dysfunction and death; (5) to develop catalytic stereoselective glycosylation mediated by organocatalysts for the synthesis of bioactive oligosaccharides and glycopeptides; and (6) to investigate rhodium/iridium-catalyzed asymmetric allylic fluorination and amination as well as regioselective radio-fluorination for potential use as pet radiotracers. overall, all of the research projects are target candidates for therapeutic drugs and pet radiotracers [ last edited by xhf402 on 2022-3-5 at 16:33 ] [ last edited by xhf402 on 2022-3-5 at 16:35 ] |
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