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liuxing3982

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[求助] 求助將中文翻譯成英文的文章摘要，不勝感激

[摘要] 本文主要是對(duì)加米霉的合成工藝進(jìn)行改進(jìn)，優(yōu)化更適合放大生產(chǎn)的工藝，通過改變中間體的純化方法，更換反應(yīng)試劑，使整個(gè)反應(yīng)過程更安全環(huán)保，成本更低；該路線以9-脫氧-9-同型紅霉素 A(E)肟為原料，在堿性催化劑的作用下生成9-脫氧-9-同型紅霉素 A(Z)肟，再經(jīng)過貝克曼重排反應(yīng)生成紅霉素亞安醚，然后經(jīng)過硼氫化鈉還原生成9-脫氧-8a-氮雜-8a-同型紅霉素A，最后經(jīng)過還原胺化反應(yīng)得到加米霉素；并且用乙腈作溶劑培養(yǎng)出加米霉素單晶，該單晶數(shù)據(jù)被英國劍橋晶體學(xué)數(shù)據(jù)庫收錄，晶體的CCDC號(hào)為1913324；加米霉素的X射線衍射單晶結(jié)構(gòu)測定表明，其結(jié)構(gòu)為單斜晶系，C2空間群，具有手性，晶胞參數(shù)：a[Å]=27.536(6)，b[Å]=9.6582(19)，c[Å]=18.529(4)，α[˚]=90β[˚]˚=114.00(3)，γ[˚]=90V[Å3]=4501.6(15)，Z=4，Dc[mg/m3]=1.177，[mm–1]=0.086，F(xiàn)(000)=1750，GOF=1.043，Rint=0.0417，R1a, wR2b[I >2σ(I)]=0.0492,0.1291，Residuals [eÅ-3]= 0.0564, 0.1354. 加米霉素晶型的確定為后續(xù)研究加米霉素制劑新劑型等方面提供新選擇。

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時(shí)間是驗(yàn)證一切的標(biāo)準(zhǔn)

1樓 2020-06-16 08:48:14

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Inorg@USF

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【答案】應(yīng)助回帖

試試啊，

Abstract

This article is mainly to improve the synthesis process of Candida, optimize the process that is more suitable for scale-up production. By changing the purification method of intermediates and replacing the reaction reagents, the entire reaction process is safer and more environmentally friendly, and lower cost. The scheme is to choose 9-deoxy-9-homo-erythromycin A(E) oxime as raw material, synthesized 9-deoxy-9-homo-erythromycin A(Z) oxime with alkaline catalyst, and produced erythromycin sulfonate through Beckmann rearrangement reaction, then reduced it with sodium borohydride to convert to 9-deoxy-8a-aza-8a-homoerythromycin A, finally undergoed reductive amination reaction to obtain gamimycin. THe single crystal of gamimycin was obtained with acetonitrile as a solvent. The crystal data is indexed in the Cambridge Crystallographic Database of the United Kingdom. The CCDC number of the crystal was 1913324; X-ray diffraction single crystal structure determination of gamimycin showed that its structure was a monoclinic system, C2 Space group, with chirality, unit cell parameters: a[Å]=27.536(6), b[Å]=9.6582(19), c[Å]=18.529(4), α[˚]=90β [˚]˚=114.00(3), γ[˚]=90V[Å3]=4501.6(15), Z=4, Dc[mg/m3]=1.177, [mm–1]=0.086, F (000)=1750, GOF=1.043, Rint=0.0417, R1a, wR2b[I >2σ(I)]=0.0492,0.1291, Residuals [eÅ-3]= 0.0564, 0.1354. Determination of the crystal form of Gamimycin provides a new option for the follow-up study of new dosage forms of Gamimycin preparations.

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There is a will,there is a way.

2樓2020-06-21 10:06:17

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